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GLP-1 cost comparison

What a pharmacy actually pays for every approved GLP-1, from the CMS acquisition-cost file — and what that says about the subscription you are being quoted.

Reviewed by
Alpha Health Finder Editorial Team
Last reviewed

Why this page starts from what a pharmacy paid

There is no authoritative public retail price for a GLP-1. Cash prices vary by pharmacy, by discount card and by week; manufacturer direct programmes change quarterly; a telehealth subscription bundles a consultation, a prescription and sometimes the drug into one figure and does not say how it splits. Any page that tells you "Wegovy costs X a month" has either quoted one pharmacy on one day or made it up.

One number in this market is published on a schedule with a methodology document. CMS surveys retail community pharmacies for what they paid on invoice and publishes the National Average Drug Acquisition Cost every week, per NDC. It is not a price you can pay — it excludes rebates, it is what the pharmacy paid rather than what it charges, and it has no relationship to a copay. What it is, is a floor: the drug does not exist below it. Every figure on this page is read from the file dated 16 September 2026, and the file and its date are printed in every caption because NADAC is republished weekly and a citation to a moving dataset without a date is not a citation.

For a GLP-1 that floor is unusually informative, because the container is fixed by the label rather than chosen by the patient. A Wegovy single-dose pen is one injection; an Ozempic 4 mg/3 mL pen is four; a Zepbound KwikPen is four of 0.6 mL. Divide the NADAC rate by the fill and then by the injections the label says the container delivers, and you have what one injection cost the pharmacy. That is the number nobody publishes and it is the axis the three findings on this page only appear on.

The first is that a pen costs what a pen costs. Every Wegovy single-dose pen in the file — 0.25 mg through 7.2 mg — is within $0.87 of the same acquisition cost, so the per-milligram figure for one product varies by a factor of 28.88x while the thing being bought does not change at all. The second is that the device matters more than the dose: Zepbound 5 mg is $263.01 as a single-dose pen and $120.54 as one of four in a KwikPen, 2.18x for an identical injection. The third is the column NADAC prints and nobody reads: a "Corresponding Generic Drug NADAC Per Unit" that is populated on three rows in the entire class, all liraglutide, and blank on every semaglutide and tirzepatide row there is.

What this page will not do is tell you what a compounded GLP-1 costs to make. Compounded semaglutide and tirzepatide have no NDC and therefore no NADAC row, and compounded semaglutide has no approved concentration at all — the strength is created when the bacteriostatic water goes in, which is why the same 25-unit mark on a syringe can be two very different doses. There is no floor to publish for them and this page publishes none.

The formula

container cost = NADAC per unit × container quantity

(quantity must be in the SAME unit NADAC prices:

mL for a pen, EA for a tablet — otherwise null)

cost per injection = container cost ÷ doses the label says it delivers

doses per month = 52 ÷ 12 = 4.333… once weekly

= 365 ÷ 12 = 30.417… once daily

acquisition / month = cost per injection × doses per month

acquisition / year = acquisition per month × 12

your multiple = what you pay per month ÷ acquisition per month

The container quantity and the dose count both come from section 3 of the FDA label, never from the carton. A month is 52 weeks ÷ 12 and 365 days ÷ 12, not four weeks and not thirty days: a 30-day month understates a daily product by 1.4%, which on Wegovy tablets is about $18 a month of cost that quietly disappears. Dollars per milligram is computed only for millilitre-priced products, because a tablet is priced as a tablet and a per-milligram figure derived from one is arithmetic without a referent.

Worked example

A recorded telehealth listing of $199 a month, set against Wegovy injection 2.4 mg in the 16 September 2026 NADAC file:

  • The NADAC rate for WEGOVY 2.4 MG/0.75 ML PEN is $435.35779 per mL, and section 3 gives the fill as 0.75 mL — so the pharmacy paid $326.52 for the pen
  • The pen is single-dose, so that is $326.52 per injection
  • Once weekly is 4.333 injections a month, so $1,415 a month of acquisition cost and $16,979 a year
  • The listing is $199 a month, which is $1,216 BELOW what the pharmacy paid, not above it
  • So the subscription cannot be supplying this product at this price. It is not a discount on Wegovy; it is a different transaction, and our catalogue does not record which
  • Run the same arithmetic against the cheapest branded weekly injectable in the file — Zepbound injection 7.5 mg in the single-patient-use kwikpen, at $522 a month — and the listing is still $323 short
  • Every one of the 10 recorded GLP-1 monthlies in our catalogue, from $80 to $260, fails that same test. That is the finding, and it is the reason to ask a provider what is in the vial rather than what the price is

Every approved semaglutide presentation, at pharmacy acquisition cost

What a retail community pharmacy paid, per the CMS NADAC file dated 16 September 2026. Not a price you can pay — see the note beneath.

Product and dosePer containerNADAC rate x fillPer injection or tabletcontainer ÷ dosesPer month4.33 weekly / 30.42 dailyPer year12 monthsPer milligramwhere it means anything
Ozempic injection 4 x 0.25 mg then 2 x 0.5 mg2 mg/3 mL pen, 6 injections$995.91per 3 mL$165.996 per container$719at the labelled cadence$8,631drug onlyNot applicablethe container holds two dose sizes
Ozempic injection 0.5 mg2 mg/3 mL pen, 4 injections$995.91per 3 mL$248.984 per container$1,079at the labelled cadence$12,947drug only$497.96per mg of drug
Ozempic injection 1 mg4 mg/3 mL pen, 4 injections$995.70per 3 mL$248.924 per container$1,079at the labelled cadence$12,944drug only$248.92per mg of drug
Ozempic injection 2 mg8 mg/3 mL pen, 4 injections$995.83per 3 mL$248.964 per container$1,079at the labelled cadence$12,946drug only$124.48per mg of drug
Wegovy injection 0.25 mg0.25 mg/0.5 mL single-dose pen$326.68per 0.5 mL$326.68one per container$1,416at the labelled cadence$16,988drug only$1,306.73per mg of drug
Wegovy injection 0.5 mg0.5 mg/0.5 mL single-dose pen$326.62per 0.5 mL$326.62one per container$1,415at the labelled cadence$16,984drug only$653.24per mg of drug
Wegovy injection 1 mg1 mg/0.5 mL single-dose pen$326.52per 0.5 mL$326.52one per container$1,415at the labelled cadence$16,979drug only$326.52per mg of drug
Wegovy injection 1.7 mg1.7 mg/0.75 mL single-dose pen$326.55per 0.75 mL$326.55one per container$1,415at the labelled cadence$16,981drug only$192.09per mg of drug
Wegovy injection 2.4 mg2.4 mg/0.75 mL single-dose pen$326.52per 0.75 mL$326.52one per container$1,415at the labelled cadence$16,979drug only$136.05per mg of drug
Wegovy HD injection 7.2 mg7.2 mg/0.75 mL single-dose pen$325.81per 0.75 mL$325.81one per container$1,412at the labelled cadence$16,942drug only$45.25per mg of drug
Rybelsus tablets 3 mg dailyOne tablet$33.16per 1 tablet$33.16one per container$1,009at the labelled cadence$12,104drug onlyNot applicablepriced per tablet, not per mg
Rybelsus tablets 7 mg dailyOne tablet$33.19per 1 tablet$33.19one per container$1,010at the labelled cadence$12,116drug onlyNot applicablepriced per tablet, not per mg
Rybelsus tablets 14 mg dailyOne tablet$33.16per 1 tablet$33.16one per container$1,009at the labelled cadence$12,104drug onlyNot applicablepriced per tablet, not per mg
Ozempic tablets 1.5 mg dailyOne tablet$33.12per 1 tablet$33.12one per container$1,007at the labelled cadence$12,088drug onlyNot applicablepriced per tablet, not per mg
Ozempic tablets 4 mg dailyOne tablet$33.15per 1 tablet$33.15one per container$1,008at the labelled cadence$12,100drug onlyNot applicablepriced per tablet, not per mg
Ozempic tablets 9 mg dailyOne tablet$33.21per 1 tablet$33.21one per container$1,010at the labelled cadence$12,123drug onlyNot applicablepriced per tablet, not per mg
Wegovy tablets 1.5 mg dailyOne tablet$43.51per 1 tablet$43.51one per container$1,324at the labelled cadence$15,883drug onlyNot applicablepriced per tablet, not per mg
Wegovy tablets 4 mg dailyOne tablet$43.48per 1 tablet$43.48one per container$1,323at the labelled cadence$15,871drug onlyNot applicablepriced per tablet, not per mg
Wegovy tablets 9 mg dailyOne tablet$43.45per 1 tablet$43.45one per container$1,322at the labelled cadence$15,860drug onlyNot applicablepriced per tablet, not per mg
Wegovy tablets 25 mg dailyOne tablet$43.41per 1 tablet$43.41one per container$1,320at the labelled cadence$15,844drug onlyNot applicablepriced per tablet, not per mg

Read down the "per injection or tablet" column and the finding is that it barely moves. Every Wegovy single-dose pen in this file, from 0.25 mg to 7.2 mg, is within $0.87 of the same figure; every Ozempic multi-dose pen delivers four injections at close to $248.92 each whichever strength it is; and every Wegovy tablet from 1.5 mg to 25 mg costs within eleven cents of every other. The milligram is not what is being sold, which is why the last column runs from $1,306.73 per mg down to $45.25 per mg across one product's own dose range — a factor of 28.88x — and why it is blank for every tablet. NADAC prices tablets per EA, and dividing a $43.41 tablet by 25 mg and a $43.51 tablet by 1.5 mg produces two numbers seventeen times apart that describe nothing.

Every approved tirzepatide presentation, at pharmacy acquisition cost

Mounjaro and Zepbound from the same 16 September 2026 file. Zepbound appears twice at each dose because it is sold in two devices.

Product and dosePer containerNADAC rate x fillPer injectioncontainer ÷ dosesPer monthonce weeklyPer yeardrug onlyPer milligramderived
Mounjaro injection 2.5 mg2.5 mg/0.5 mL single-dose pen$269.32per 0.5 mL$269.32one per container$1,167at the labelled cadence$14,005drug only$107.73per mg of drug
Mounjaro injection 5 mg5 mg/0.5 mL single-dose pen$269.30per 0.5 mL$269.30one per container$1,167at the labelled cadence$14,003drug only$53.86per mg of drug
Mounjaro injection 7.5 mg7.5 mg/0.5 mL single-dose pen$269.31per 0.5 mL$269.31one per container$1,167at the labelled cadence$14,004drug only$35.91per mg of drug
Mounjaro injection 10 mg10 mg/0.5 mL single-dose pen$269.32per 0.5 mL$269.32one per container$1,167at the labelled cadence$14,004drug only$26.93per mg of drug
Mounjaro injection 12.5 mg12.5 mg/0.5 mL single-dose pen$269.24per 0.5 mL$269.24one per container$1,167at the labelled cadence$14,000drug only$21.54per mg of drug
Mounjaro injection 15 mg15 mg/0.5 mL single-dose pen$269.24per 0.5 mL$269.24one per container$1,167at the labelled cadence$14,000drug only$17.95per mg of drug
Zepbound injection 2.5 mg2.5 mg/0.5 mL single-dose pen$263.06per 0.5 mL$263.06one per container$1,140at the labelled cadence$13,679drug only$105.22per mg of drug
Zepbound injection 5 mg5 mg/0.5 mL single-dose pen$263.01per 0.5 mL$263.01one per container$1,140at the labelled cadence$13,676drug only$52.60per mg of drug
Zepbound injection 7.5 mg7.5 mg/0.5 mL single-dose pen$262.89per 0.5 mL$262.89one per container$1,139at the labelled cadence$13,670drug only$35.05per mg of drug
Zepbound injection 10 mg10 mg/0.5 mL single-dose pen$262.89per 0.5 mL$262.89one per container$1,139at the labelled cadence$13,670drug only$26.29per mg of drug
Zepbound injection 12.5 mg12.5 mg/0.5 mL single-dose pen$262.89per 0.5 mL$262.89one per container$1,139at the labelled cadence$13,670drug only$21.03per mg of drug
Zepbound injection 15 mg15 mg/0.5 mL single-dose pen$262.85per 0.5 mL$262.85one per container$1,139at the labelled cadence$13,668drug only$17.52per mg of drug
Zepbound injection 2.5 mg10 mg/2.4 mL KwikPen, 4 injections$482.28per 2.4 mL$120.574 per container$522at the labelled cadence$6,270drug only$48.23per mg of drug
Zepbound injection 5 mg20 mg/2.4 mL KwikPen, 4 injections$482.16per 2.4 mL$120.544 per container$522at the labelled cadence$6,268drug only$24.11per mg of drug
Zepbound injection 7.5 mg30 mg/2.4 mL KwikPen, 4 injections$481.67per 2.4 mL$120.424 per container$522at the labelled cadence$6,262drug only$16.06per mg of drug
Zepbound injection 10 mg40 mg/2.4 mL KwikPen, 4 injections$675.26per 2.4 mL$168.814 per container$732at the labelled cadence$8,778drug only$16.88per mg of drug
Zepbound injection 12.5 mg50 mg/2.4 mL KwikPen, 4 injections$678.03per 2.4 mL$169.514 per container$735at the labelled cadence$8,814drug only$13.56per mg of drug
Zepbound injection 15 mg60 mg/2.4 mL KwikPen, 4 injections$672.06per 2.4 mL$168.024 per container$728at the labelled cadence$8,737drug only$11.20per mg of drug

Mounjaro and Zepbound are the same molecule at the same six strengths on the same weekly schedule, and Mounjaro's pens are consistently the dearer of the two — $269.24 against $262.85 at 15 mg. Neither label contains a dosage difference that would explain it. The much larger gap is inside Zepbound's own range: the KwikPen is 2.18x cheaper per injection than the single-dose pen at the three lower doses and around 1.56x cheaper at the three upper ones, for an injection the label describes identically. That is the next table.

The same Zepbound injection, in two devices

Identical molecule, identical dose, identical weekly schedule. The only difference is whether the drug arrives as one single-dose pen or as one of four doses in a KwikPen.

Dose per injectionSingle-dose pen0.5 mL, one injectionKwikPen2.4 mL, four injectionsSaved per injectionby the KwikPenMultiplesingle ÷ multiSaved per yearat the labelled cadence
2.5 mginitiation only, per the label$263.06$1,140 a month$120.57$522 a month$142.49$617 a month2.18xper identical injection$7,409acquisition cost only
5 mga labelled maintenance dosage$263.01$1,140 a month$120.54$522 a month$142.47$617 a month2.18xper identical injection$7,408acquisition cost only
7.5 mga titration step$262.89$1,139 a month$120.42$522 a month$142.47$617 a month2.18xper identical injection$7,409acquisition cost only
10 mga labelled maintenance dosage$262.89$1,139 a month$168.81$732 a month$94.07$408 a month1.56xper identical injection$4,892acquisition cost only
12.5 mga titration step$262.89$1,139 a month$169.51$735 a month$93.38$405 a month1.55xper identical injection$4,856acquisition cost only
15 mga labelled maintenance dosage$262.85$1,139 a month$168.02$728 a month$94.84$411 a month1.56xper identical injection$4,931acquisition cost only

This is the single largest cost difference in the whole dataset that has nothing to do with the drug. The saving is widest at 2.5, 5 and 7.5 mg, where the KwikPen is 2.18x cheaper per injection, and narrows to about 1.56x from 10 mg upward because the KwikPen's own NADAC rate steps up there. Two cautions before anyone acts on it. First, these are acquisition costs and not prices: nothing here says a pharmacy, a plan or a manufacturer savings card passes the difference on, and the KwikPen has been in shorter supply than the single-dose pens. Second, the devices are not interchangeable at the counter — which one you get is a function of what was prescribed and what the pharmacy has, not a menu. The useful version of this finding is a question to ask, not a number to expect.

Liraglutide — the only GLP-1 in the file with a generic

Brand and generic side by side at the doses each label names. The pairings are NADAC's own: the file prints a "Corresponding Generic Drug NADAC Per Unit" beside each brand row.

Product and dosePer pen18 mg/3 mLPer dayat this dosePer month30.42 daysPer yeardrug onlyPer milligramderived
Victoza (brand) 1.2 mg daily3 mL pen, 15 days at 1.2 mg$263.44per 3 mL pen$17.56per day$534per month$6,410per year$14.64per mg of drug
Victoza (brand) 1.8 mg daily3 mL pen, 10 days at 1.8 mg$263.44per 3 mL pen$26.34per day$801per month$9,616per year$14.64per mg of drug
Liraglutide (generic) 1.2 mg daily3 mL pen, 15 days at 1.2 mg$96.01per 3 mL pen$6.40per day$195per month$2,336per year$5.33per mg of drug
Liraglutide (generic) 1.8 mg daily3 mL pen, 10 days at 1.8 mg$96.01per 3 mL pen$9.60per day$292per month$3,504per year$5.33per mg of drug
Saxenda (brand) 3 mg daily3 mL pen, 6 days at 3 mg$261.41per 3 mL pen$43.57per day$1,325per month$15,903per year$14.52per mg of drug
Liraglutide (generic) 3 mg daily3 mL pen, 6 days at 3 mg$143.08per 3 mL pen$23.85per day$725per month$8,704per year$7.95per mg of drug

The three rows NADAC itself pairs are VICTOZA 3-PAK 18 MG/3 ML PEN at $87.81 per mL against $32.00 generic (2.74x), VICTOZA 2-PAK 18 MG/3 ML PEN at $87.74 per mL against $33.82 generic (2.59x), SAXENDA 18 MG/3 ML PEN at $87.14 per mL against $47.69 generic (1.83x). That column is blank on every semaglutide and tirzepatide row in the file, which is the same statement as: semaglutide and tirzepatide have no generic in the United States, and nothing on this page will change until they do. Generic liraglutide at the Victoza maintenance dose is $195 a month of acquisition cost, which is the only figure in this entire dataset that is even the same order of magnitude as what a telehealth subscription charges. Liraglutide is a daily injection rather than a weekly one, it was approved in 2010, and it is materially less effective for weight reduction than either newer molecule — the point of this table is the existence of the generic column, not a recommendation. One caveat on the per-day column: it divides 18 mg by the daily dose, and lib/liraglutide-dosing records two label facts that make that an upper bound on the doses a pen yields — a remainder is not a dose, and every new pen is flow-checked before its first injection with no label stating how much solution that uses. The real cost per day is therefore at or above what is printed here.

What our recorded telehealth listings charge, against the published floor

Every GLP-1 monthly in our provider catalogue that states a per-month period, ordered by price because that is a lookup order. The floor is the cheapest branded weekly injectable in the 16 September 2026 file.

Provider and planListed monthlyas the provider states itA yeartwelve of the sameCheapest branded weeklyZepbound injection 7.5 mgDifferencelisting minus floorCovers the branded drug?on arithmetic alone
MaximusSemaglutide Weight Loss$80pricing tier$960at the listed rate$522pharmacy acquisition−$442below the floorNothe listing is below acquisition
MaximusTirzepatide Weight Loss$132pricing tier$1,584at the listed rate$522pharmacy acquisition−$390below the floorNothe listing is below acquisition
DudeMedsGLP-1 programme$149category listing$1,788at the listed rate$522pharmacy acquisition−$373below the floorNothe listing is below acquisition
PeterMDGLP-1 Weight Loss$149pricing tier$1,788at the listed rate$522pharmacy acquisition−$373below the floorNothe listing is below acquisition
Strut HealthSemaglutide (Weight Loss)$149pricing tier$1,788at the listed rate$522pharmacy acquisition−$373below the floorNothe listing is below acquisition
HimsGLP-1 Weight Loss$199pricing tier$2,388at the listed rate$522pharmacy acquisition−$323below the floorNothe listing is below acquisition
ShedSemaglutide Injections$199pricing tier$2,388at the listed rate$522pharmacy acquisition−$323below the floorNothe listing is below acquisition
ShedTirzepatide Injections$199pricing tier$2,388at the listed rate$522pharmacy acquisition−$323below the floorNothe listing is below acquisition
ShedGLP-1 Drops/Lozenges$199pricing tier$2,388at the listed rate$522pharmacy acquisition−$323below the floorNothe listing is below acquisition
MangoRxWeight Loss (Slim)$260pricing tier$3,120at the listed rate$522pharmacy acquisition−$262below the floorNothe listing is below acquisition
Romanlisted under weight lossNo monthly recordedcatalogue holds "$15"Not computednothing to annualise$522pharmacy acquisitionNot computedno listing to subtractUnknownno price to reason from
Sesame Carelisted under weight lossNo monthly recordedcatalogue holds "$19"Not computednothing to annualise$522pharmacy acquisitionNot computedno listing to subtractUnknownno price to reason from

Two things this table is doing, and one it is not. It is applying the same period guard the TRT cost calculator uses: a listing is only charted as a monthly where it states a per-month period, which is why Roman and Sesame Care appear with no figure. Roman's catalogue entry in this category is "$15", an entry price for a different treatment, and charting it as a GLP-1 monthly is exactly the error the guard was written after. It is also doing one subtraction: every recorded subscription from $80 to $260 sits below $522, which is what a pharmacy paid for a month of the cheapest branded weekly injectable in the file. That has exactly one implication and it is arithmetic: the subscription price is not buying branded medication at that price. It may be buying a compounded preparation, the medication may be billed separately, or the figure may be a consultation-and-membership price. Our catalogue records what each provider states and does not record which of those it is. What this table is NOT doing is ranking anyone — for that, see /best.

Frequently asked questions

How much does Wegovy cost per month without insurance?
This page will not give you that figure, because no one publishes it and every page that states one has quoted a single pharmacy on a single day. What is published is what pharmacies paid: in the CMS NADAC file dated 16 September 2026, a WEGOVY 2.4 mg single-dose pen cost a retail community pharmacy $326.52, which at one injection a week is $1,415 a month and $16,979 a year. Your cash price is above that, and how far above depends on the pharmacy's markup, your plan and any manufacturer programme. The acquisition cost is a floor, not a quote.
Is the Zepbound KwikPen cheaper than the single-dose pen?
At pharmacy acquisition cost, substantially — and for an identical injection. In the 16 September 2026 file a 5 mg dose is $263.01 as a single-dose pen and $120.54 as one of four doses in a KwikPen, which is 2.18x and works out at $7,409 a year. The gap narrows to about 1.56x at 10 mg and above. Two cautions: an acquisition cost is not a price, so nothing guarantees the difference reaches you, and the two devices are not interchangeable at the counter — which one you get depends on the prescription and on stock.
Is there a generic Ozempic or generic Zepbound?
No. In the 16 September 2026 NADAC file, the "Corresponding Generic Drug NADAC Per Unit" column is populated on exactly three rows in the entire GLP-1 class, and all three are liraglutide: VICTOZA 3-PAK 18 MG/3 ML PEN at $87.81 per mL against $32.00 for the generic, a factor of 2.74x. Every semaglutide and every tirzepatide row leaves it blank. Compounded semaglutide is not a generic — a generic is an approved product with a demonstrated bioequivalence to the brand, and compounded preparations are neither approved nor required to demonstrate it.
Why is a 0.25 mg Wegovy pen the same price as a 7.2 mg one?
Because the pen is what is priced, not the drug in it. Every Wegovy single-dose pen in the 16 September 2026 file is within $0.87 of the same acquisition cost across the whole 0.25 mg to 7.2 mg range, and the same pattern holds for Ozempic's pens, Mounjaro's pens and every Wegovy tablet from 1.5 mg to 25 mg. One consequence is that dollars-per-milligram is nearly meaningless here: for Wegovy it runs from $1,306.73 per mg at the starting dose down to $45.25 at 7.2 mg, a factor of 28.88x, while the thing being bought does not change. It also means the titration weeks cost exactly as much as maintenance.
How much does compounded semaglutide actually cost to make?
No figure here, and be sceptical of anyone who gives you one. Compounded preparations have no National Drug Code, so they are absent from NADAC and from every other published acquisition dataset; there is no approved concentration for compounded semaglutide, so there is no milligrams-per-millilitre to price against; and the strength is created when the bacteriostatic water is added rather than being a property of what was shipped. What can be said is what the branded products cost a pharmacy, which is in the tables above, and that every telehealth GLP-1 subscription we have recorded is priced below that floor.
Why is a $199 GLP-1 subscription cheaper than what a pharmacy pays?
Because it is a different transaction, and the arithmetic says so before anyone has to speculate. A month of the cheapest branded weekly injectable in the 16 September 2026 file cost a pharmacy $522; a month of Wegovy 2.4 mg cost $1,415. Every recorded GLP-1 monthly in our catalogue, from $80 to $260, is below both. A subscription at that price is therefore not supplying the branded product at that price — it may be dispensing a compounded preparation, it may bill the medication separately, or the fee may cover the consultation and membership only. Ask which before you compare two subscriptions on price.
Does this include the cost of needles, labs or the consultation?
No. Every figure above is drug acquisition cost and nothing else. The branded pens are self-contained so there are no separate needles to buy, but a GLP-1 programme in practice also carries a consultation, follow-ups and often baseline bloods, and a telehealth subscription usually bundles those into the monthly. That is one reason a $199 subscription and a $1,415 acquisition cost are not comparable quantities: one is a service with a drug attached and the other is the invoice price of a box. The tables keep them in separate columns for that reason.
Why does Mounjaro cost more than Zepbound for the same molecule?
On the acquisition side it does, consistently: $269.24 against $262.85 for a 15 mg single-dose pen in the 16 September 2026 file, and the same ordering at every strength. Nothing in either label explains it — the ladder, the increment, the interval and the maximum are identical, and the difference is the indication each is approved for. That is a pricing decision by the manufacturer, not a clinical one, and it is worth knowing only because it is the kind of gap that does not survive into what anyone is charged: the two products are not substitutable and a prescription for one cannot be filled with the other.

Sources

  1. [1]CMS Medicaid National Average Drug Acquisition Cost (NADAC), weekly file dated 16 September 2026 — the per-NDC acquisition rates every figure on this page is computed from. Filtered to semaglutide, tirzepatide and liraglutide rows whose As of Date is 09/16/2026
  2. [2]CMS Medicaid NADAC dataset landing page — methodology, weekly publication schedule and the Data Field Definitions describing the Pricing Unit and Corresponding Generic Drug columns
  3. [3]WEGOVY (semaglutide) injection and tablets — full US prescribing information, Novo Nordisk. Section 3 Dosage Forms and Strengths: the single-dose pen fill volumes and the tablet strengths every container figure here is derived from. DailyMed set id ee06186f-2aa3-4990-a760-757579d8f77b
  4. [4]OZEMPIC (semaglutide) injection — full US prescribing information, Novo Nordisk. Section 3, verbatim: "Injection: 2 mg/3 mL (0.68 mg/mL) for 4 doses of 0.25 mg and 2 doses of 0.5 mg or 4 doses of 0.5 mg, 4 mg/3 mL (1.34 mg/mL) for 4 doses of 1 mg, and 8 mg/3 mL (2.68 mg/mL) for 4 doses of 2 mg". DailyMed set id adec4fd2-6858-4c99-91d4-531f5f2a2d79
  5. [5]RYBELSUS and OZEMPIC (oral semaglutide) tablets — full US prescribing information, Novo Nordisk. Section 3 tablet strengths and section 2.2 once-daily dosing. DailyMed set id 27f15fac-7d98-4114-a2ec-92494a91da98
  6. [6]ZEPBOUND (tirzepatide) injection — full US prescribing information, Eli Lilly and Company. Section 3 single-dose pen and KwikPen presentations, section 2.1 once-weekly dosing. DailyMed set id 487cd7e7-434c-4925-99fa-aa80b1cc776b
  7. [7]MOUNJARO (tirzepatide) injection — full US prescribing information, Eli Lilly and Company. Section 3 single-dose pen strengths. DailyMed set id d2d7da5d-ad07-4228-955f-cf7e355c8cc0
  8. [8]VICTOZA (liraglutide) injection — full US prescribing information, Novo Nordisk. Section 3, verbatim: "Injection: 18 mg/3 mL (6 mg/mL) clear, colorless solution in a prefilled, single-patient-use pen that delivers doses of 0.6 mg, 1.2 mg, or 1.8 mg". DailyMed set id 5a9ef4ea-c76a-4d34-a604-27c5b505f5a4
  9. [9]SAXENDA (liraglutide) injection — full US prescribing information, Novo Nordisk. Section 3, verbatim: "Injection: 6 mg/mL clear, colorless solution in a 3 mL prefilled, single-patient-use pen that delivers doses of 0.6 mg, 1.2 mg, 1.8 mg, 2.4 mg, or 3 mg". DailyMed set id 3946d389-0926-4f77-a708-0acb8153b143
  10. [10]U.S. Food and Drug Administration — FDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss, on compounded semaglutide and tirzepatide and the absence of approved labelling

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Educational reference, not medical advice. These are pharmacy acquisition costs, not prices. NADAC is what retail community pharmacies reported paying on invoice; it excludes rebates, it is not a cash price, it is not a copay and no patient can buy at it. Nothing here is a recommendation to switch product, device or provider — which GLP-1 is appropriate, and in which device, is a decision for your prescriber, and a cheaper acquisition cost is not a reason to change a treatment that is working.